Preheat oven to 450 degrees.
Crumbled ground beef and ground pork in a large bowl and pour in one cup of panko breadcrumbs.
In a separate small bowl, mix together the wet ingredients - milk, eggs, and Worcestershire sauce. Once combined, pour them into the bowl with the meat mixture.
Add ½ cup grated Parmesan cheese, parsley, onion, oregano, garlic, salt, pepper, and red pepper flakes to the meatball mixture and combine thoroughly with clean hands.
Wet your hands with a small amount of water to prevent the meat from sticking to your skin and form golf ball size meatballs by rolling the meat mixture between the palms of your hands.
Prepare the meatball breading by mixing together 1 cup of panko breadcrumbs with ½ cup grated Parmesan cheese, and 4 teaspoons of olive oil in a dish. Combine the breading well to ensure the breadcrumbs soak up the oil.
Coat the meatballs with the panko breading by rolling each meatball in the panko mixture until coated on each side.
Place breaded meatballs on a rimmed baking sheet and bake meatballs in the oven for 15 minutes or until the internal temperature has reached 165 degrees and the exterior is golden brown.